Oral magnesium supplementation improves the metabolic profile of metabolically obese, normal-weight individuals: a randomized double-blind placebo-controlled trial.
Arch Med Res. 2014 Jul;45(5):388-93. doi: 10.1016/j.arcmed.2014.05.003. Epub 2014 May 13.
Rodríguez-Moran M1, Guerrero-Romero F2 guerrero.romero at gmail.com
Author information
1 Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
2 Biomedical Research Unit, Mexican Social Security Institute, Durango, Mexico.
Magnesium Chloride containing 386 mg Mg
Both obese and normal weight individuals had similar benefit
| Mg | Control | |
| Systolic blood pressure | -2 mm | +4 mm |
| Diastolic blood pressure | -4 mm | +8 mm |
| HOMA-IR index | -47%. | -5% |
| Fasting glucose | -12% | -2% mg/dL |
| Triglyceride levels | -47% | 10% |
See also VitaminDWiki
- Search VitaminDWiki for HOMA-IR 86 items as of Oct 2014
- 4000 IU RCT reduces type 2 diabetes HOMA by 24% and CRP by 64% April 2010
- Overview Magnesium and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
553 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 57 ; Meta-analysis 40 ; Obesity 36 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 13 ; Magnesium 30 Click here to see details Some Diabetes studies
- Take Vitamin D to prevent prediabetes from progressing into diabetes – American Diabetic Association – 2024
- Diabetes and Vitamin D meta-analyses - many studies 39+ as of Nov 2024
- 99.7% of people who got Diabetes had been regularly consuming food emulsifiers - May 2024
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
The TOP Metabolic Syndrom articles are here:- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Metabolic Syndrome 10% less likely for every 4 ng increase in Vitamin D – Jan 2013
- Metabolic Syndrome risk reduced 60 percent if high level of active vitamin D – Nov 2014
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- The Role of Magnesium in the Pathogenesis of Metabolic Disorders – April 2022
BACKGROUND AND AIMS:
We undertook this study to determine the efficacy of oral magnesium supplementation in the improvement of the metabolic profile and blood pressure in metabolically obese, normal-weight (MONW) individuals.
METHODS:
A total of 47 MONW individuals with hypomagnesemia were enrolled in clinical a randomized double-blind placebo-controlled trial. Individuals in the intervention group received 30 mL of MgCl2 5% solution (equivalent to 382 mg of magnesium) and individuals in the control group 30 mL of placebo solution, once daily during 4 months. In the absence of obesity or overweight, the presence of fasting glucose levels ≥100 mg/dL, HOMA-IR index ≥3, triglyceride levels ≥150 mg/dL and/or systolic and diastolic blood pressure ≥140 and 90 mmHg defined the presence of the MONW phenotype. Hypomagnesemia was defined by serum magnesium concentration ≤1.8 mg/dL.
RESULTS:
At basal conditions there were no significant differences between groups. At the end of follow-up, changes in the mean of systolic (-2.1 vs. 3.9% mmHg, p <0.05) and diastolic (-3.8 vs. 7.5% mmHg, p <0.05) blood pressures, HOMA-IR index (-46.5 vs. -5.4%, p <0.0001), fasting glucose (-12.3 vs. -1.8% mg/dL, p <0.05) and triglyceride levels (-47.4% vs. 10.1% mg/dL, p <0.0001) were significantly lower in the subjects who received MgCl2 compared with individuals in the control group.
CONCLUSIONS:
Oral magnesium supplementation improves the metabolic profile and blood pressure of MONW individuals.Copyright © 2014 IMSS. Published by Elsevier Inc. All rights reserved.
PMID: 24830937
Daily Magnesium improved all aspects of metabolic profile – RCT July 2014(Cached) Printer Friendly Follow this page for updates8186 visitors, last modified 28 Oct, 2014, This page is in the following categories (# of items in each category)